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Journal > Journal of the Indonesian Medical Association > The Effect of Lumbricus rubellus in Treatment of Patient with Typhoid Fever

 

Journal of the Indonesian Medical Association
Vol. 63 No. 2 February 2013
The Effect of Lumbricus rubellus in Treatment of Patient with Typhoid Fever
Nugroho, Agung ( Faculty of Medicine Universitas Sam Ratulangi, Manado)
Datau, Euis Alwi ( Faculty of Medicine Universitas Sam Ratulangi, Manado)
Purwitanto, Purwitanto ( Faculty of Medicine Universitas Sam Ratulangi, Manado)
Article Info   ABSTRACT
Published date:
28 Feb 2013
 
Introduction: Typhoid fever remains a global health problem. A large use of antibiotics can leadto resistance and allergy medications. Treatment with traditional ingredients earthworm has longbeen used to treat typhoid fever. Several studies have proven the earthworm Lumbricus rubellus extract can inhibit the growth of Salmonella typhi in vitro.Objective: To determine the effect of the addition of L. extract ciprofloksasin rubellus on thetreatment of patients with typhoid fever.Methods: A double-blind clinical trials of experimental placebo-controlled trial conducted in RSI Sitti Mariam from January 2012 until July 2012.Results: It was found that 52 samples consisting of 26 treatment and 26 control samples. Therewas no significant difference in the loss of a fever. In the treatment group, the average fever waslost at 39.46 to 34.38 while in control, not significantly different. There is no significant difference in the frequency of use of antipyretics both groups and both groups the number of gastrointestinal symptoms, and laboratory values.Conclusion: The addition of extracts L.rubellus on ciprofloksasin no effect on the long fever,antipyretic administration, gastrointestinal disorders, hemoglobin, leukocyte count, platelet count, SGOT, SGPT, and does not adversely affect the side effects of treatment. J Indon Med Assoc. 2013;63:58-62.Keywords: Typhoid fever, treatment, ciprofloksasin, extract of Lumbricus rubellus
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